Administration may be two times a week for one month, more likely 3 or 4 or more days per week, and treatments may to on for several weeks or months, often at least 3 months. In another aspect of the invention, the active agent is combined with a potentiator, either directly or in vivo. Nature Clinical Practice: Urology, March 2005. If a 70-100 erection is not achieved within 20 minutes of the first test dosage amount administered by intracavernosal injection, a second injection of less, the same or more of the composition as the initial test injection, depending. Also, engorgement can include a 40-75 erectile response for at least 3 hours.
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For example, the potentiator Potaba may be administered orally and the composition administered intracavernosally. 5, contents, surgical methods. Oderda M Gontero P, "Non-invasive methods of penile lengthening: Fact or fiction?", BJU Int, 2011 Apr; 107 (8 127882. 20 Despite many anecdotal reports of success, medical evidence is absent. Relaxin receptors are found in the brain heart, skin, nipples, small intestine, mammary gland, blood vessels, and testes. Because of great risk and uncertainty, medical professionals are generally skeptical of penile enlargement and avoid attempting. The potentiator can be formulated for administration to the dorsal suspensory ligand of the penis, or for intracavernosal injection, or for administration by an implantable sustained release drug or device. 8 9 The American Urological Association (AUA) and the Urology Care Foundation "consider subcutaneous fat injection for increasing penile girth to be a procedure which has not been shown to be safe or efficacious. Optionally, the kit may also include an agent which will potentiate the effects of the pharmaceutical compositions of this invention. Can You Enlarge.
5, most men seeking penis enlargement have normal-size penises, and many may experience penile dysmorphophobia by underestimating their own penis size while overestimating the average size. "Penile enlargement: from medication to surgery". Preferably, the measurement is taken when the penis is fully erect. The use of external weights is cumbersome and impractical and produces localized compressive forces that may cause localized ischemia. For intracavernosal injections, first dosage amounts may range from about.5 mcg to about 30 mcg of prostaglandin E1, and more preferably from 1 mcg to 6 mcg. A softer less firm adams penis enlarger eqipment response can be safely and comfortably maintained for a greater length of time than a full erection. Talk Sex with Sue Johanson. Relaxin might be for topical administration at a dosage of 25 to 400 micrograms/kg body weight/day. There is also significant overlap between techniques intended to enlarge the penis and techniques intended to achieve other, related objectives, such as reversing impotence, extending the duration of erections, or enhancing sexual climax.
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Sometimes an endpoint is chosen after a degree of enlargement is obtained, say 5 (length, and/or girth) within 12 to 18 months, for example. Once the appropriate dosage for a given patient has been determined, the treatment may be self-administered under the close supervision of a properly trained physician or health professional. The pharmaceutical composition comprises a pharmaceutically acceptable vasodilator for causing a prolonged suitable engorgement of the penis, together with a pharmaceutically acceptable diluent or carrier. The pharmaceutical composition can be such that the potentiator is for administration more than once both separately from and concurrently with the composition. Ian Kerner, sex counselor, author, She Comes First and, love in the Time of Colic, New York. While some products contain ingredients generally recognized as safe, others contain questionable ingredients, sometimes undisclosed. The quantity of medication was adjusted from time to time in accordance with the patient's response, which was monitored initially weekly then monthly once the patient had mastered the IC technique and the responses were consistently of the same duration. Because our price on this item adams penis enlarger eqipment is lower than the manufacturer's suggested retail price, the manufacturer does not allow us to show you our price until you place the item in your shopping cart. A male patient, age 72, was treated with intracavernosal injections of the quadruple mix of the vasodilators prostaglandin E1, Atropine, Chlorpromazine and Papavarine on a regular basis (approximately two to four times per week) over a 3-month treatment. For example, a ring designed to fit around the base of the penis might be used. Retrieved b Wanjek, Christopher (February 20, 2007). According to the method, such an administration lasts for a limited time during one day, and is repeated up to daily or a few days a week over a period of several weeks.
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A male patient, age 47, was treated with intracavernosal injections of a triple mix of the vasodilators Atropine, Chlorpromazine and Papavarine on a regular basis (approximately three to four times per week) over a 6-month treatment period. Other patients may require two doses, one at the beginning of a daily treatment, and one or more later one during the same treatment so as to maintain the engorgement, say above 40 engorgement. For example, the potentiator may be an androgen hormone such as, but not limited to, the naturally occurring androgens and derivatives thereof, including androsterone, androsterone acetate, androsterone propionate, androsterone benzoate, androstenediol, androstenediol-3-acetate, androstenediol-17-acetate, androstenediol-3,17-diacetate, androstenediol-17-benzoate, androstenedione, dehydroepiandrosterone (dhea; also termed prasterone sodium dehydroepiandrosterone. The skin of the penis is hypermobile, and only very loosely connected to deeper connective tissues and structures that comprise the erectile tissues of the penis. 24 Society and culture This section needs expansion. As of 2013, the majority of research investigating the use of penile traction focuses on treating the curvature and shrinkage of the penis as a result of Peyronie's disease, although some literature exists on the impact on men with short penises. The vasodilator may be a drug typically used to treat erectile dysfunction, but administered at a similar or higher dosage or sequentially as two or more lesser doses to achieve a prolonged period of engorgement followed by an additional period of lesser engorgement. A b Qian SQ, Gao L, Wei Q Yuan J, "Vacuum therapy in penile rehabilitation after radical prostatectomy: Review of hemodynamic and antihypoxic evidence", Asian Journal of Andrology, 2016 MayJun;18(3 44651. The subject's condition should be monitored and the dosage adjusted to ensure that the patient experiences a prolonged period of engorgement, rather than a prolonged full erection, which may lead to priapism and associated health complications. international Journal of Impotence Research, 2002. Following the discontinuation of this treatment, the erect penis length remained stable for two years at over 8 inches.
26, 2002, and PCT/CA2003/001139, filed Jul. Also called "milking 19 the technique has ancient Arab origins. In order that the invention may be better understood, preferred embodiments will now be described in the following examples. More preferably, the treatment may be repeated at least 3-4 times a week for a period of at least 3 months. Also, any suction forces applied to the penis will have a proportionately larger effect on the skin, and the forces on the deeper structures diminish dramatically. Journal of Sex Marital Therapy. The 15 mg of the potentiator Dihydrotestosterone was injected subcutaenously into the penis daily throughout the treatment period. The size of the patient's fully erect penis increased from.0 inches.3 inches in length,.e. The potentiators Potaba 1000 mg 4/day orally and prostaglandin F topically were also used with the vasodilators. Treatment was re-institued combining intracavernosal injections 3-4 times per week of a mixture of testosterone (0.5 mg) and vasodilators with low dose oral Potaba (500-1000 mg) 3-4 times per day. If there was no response, the same or more than the amount of the first dosage amount may be administered. For example, relaxin may be administered by intracavernosal injection at a dosage ranging from.01 to 50 mcg/kg body weight/day, more preferably at a dosage ranging from.02 to 10 mcg/kg body weight/day, or topically at a dosage ranging. Preferably, the vasodilator is selected from the group consisting of papaverine, chlorpromazine, atropine, phentolamine, and prostaglandin E1, and mixtures thereof.
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The firmness of the penis generally decreases over this period, but will be at least 40 engorged for at least 3 and preferably up to 6 hours and less than 75 engorged for the majority of the time. Using these general guidelines a maximum of two injections are administered per visit. A sufficient quantity of vasodilator was administered to maintain a prolonged engorgement of an erectile response greater than 70 for.5-5 hours duration. The potentiator may be administered as part of the composition, separately from the composition, or a combination of both. The hormone can be an androgen selected from the group consisting of, but not limited to, the naturally occurring androgens and derivatives thereof, or any agent that will stimulate the androgen receptor directly or indirectly, including androsterone, androsterone acetate, androsterone propionate, androsterone benzoate, androstenediol, androstenediol-3-acetate.
Although various examples of combined elements of the invention have been described, it will also be understood that these are not intended to be exhaustive and features of one embodiment may be combined with those of another, and such other. A physician should closely monitor the subject's response to medication, to determine signs of edema, tenderness, and other early signs that the dose is excessive and needs adjusting. After 5 months of treatment the patient's erect penis increased from.0 inches.1 inches (about an 18 increase) in length. The potentiator may be a pharmacological agent or combination of agents that promote cellular processes that result in biological and/or mechanical creep and ultimately induce remodelling of the connective tissues that help define the size and shape of the penis. Although it is known in the prior art that vasodilators can be administered to a male to induce engorgement of the penis, the prior art is silent on the period of engorgement. (December 2017) In 2013 in Vietnam, many Vietnamese men attempted self penis enlargement by injecting liquid silicone into their penises, and subsequently suffered from complications such as infections, necrosis, tumors, swelling, deformities, sexual dysfunction, and were hospitalized. 21 22 Traction One type of traction device Traction is a nonsurgical method to lengthen the penis by employing devices that pull at the glans of the penis for extended periods of time.
Testosterone is converted to 4-dihydrotestosterone(DHT) by the enzyme 5 alpha-reductase in many peripheral tissues. The vasodilator drug may be one which either directly or indirectly causes vasodilation and may be classified, without limitation, in one of the following categories, namely, nitrovasodilators, ACE inhibitors, angiotensin receptor antagonists, phosphodiesterase adams penis enlarger eqipment inhibitors, direct vasodilators, adrenergic receptor antagonists, calcium. 17 18 Jelqing Performed on the halfway tumescent penis, jelqing is a manual manipulation of simultaneous squeezing and stroking the shaft from base to corona. A sufficient quantity was administered to maintain a prolonged engorgement over a period of about 3 to 5 hours. A preferred vasodilator is prostaglandin.
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However, unlike many other pro-hormones, pro-relaxin retains its biological activity. The amount of the first dosage given will be determined, among other things, by the route of intended administration, the age of the man, the recent history of erectile function of the man, and pre-existing health conditions of the man. The quantity of medication was adjusted from time to time in accordance with the patient's response, which was monitored initially weekly. Typically, the initial erectile response is at least. Preferably, the vasodilator is prostaglandin E1, alone or with other vasodilators, administered as one or more doses that are typically lower than what would be used to treat erectile dysfunction. 3, some adams penis enlarger eqipment quack products may improve penis erection, mistaken by consumers for penis enlargement.
A adams penis enlarger eqipment male patient, age 52, was treated with separate intracavernosal injections of vasodilators, Papavarine, phentolamine and prostaglandin E1, on a regular basis, selected from treatments of 0 to 4 times per week, over a 7 month treatment period along with daily. Retrieved July 14, 2014). A b Vardi Y, "Is penile enlargement an ethical procedure for patients with a normal-sized penis?", Eur Urol, 2006 Apr; 49 (4 609-11. Some surgical methods have the most evidence of effectiveness, whereas others have fairly frequent complications, sometimes severe, including scarring that lead, ultimately, to penis shrinkage or erectile dysfunction. The engorgement period is thus usually at least 3 hours, but may be 3 hours, 4 hours, 4 hours, 5 hours, 5 hours, even up to 6 hours, but heavy engorgement of a penis, say 40 or more,.
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The potentiator can thus be formulated for administration by direct injection to the cavernosal tissue, by needle, auto-injector, slow sustained injection pump, high pressure injection device, micro pump infusion, urethral suppository, or implantable sustained release drug or device, etc. As explained in greater detail below, the permanent increase in size is achieved by repeated use of the vasodilator or composition thereof, say, once a day for a few days a week over many weeks, possibly many months. Once a starting dosage amount of a single or a sequence of two or more injections is established that provides a response of suitable duration, the dosage may be titrated, for example, to provide the subject with an initial 70-100. After 2 months of treatment subcutaneous injections of testosterone 14-20 mg into the penis adams penis enlarger eqipment were added as an accelerator. This invention provides the use of pharmacological vasodilators to cause a permanent increase in the length and girth of a human penis. Health, Center for Devices and Radiological. After a short treatment period of 2 months, the patient's erect penis was over 9 inches in length, which means he has gained an additional.4-0.5 inches in length (about an 6 increase). In fact, due to the prolonged elevation in penile blood flow, patients using this treatment will experience a very significant increase in erectile function. This may be in the form of a depot oil. Applying a suction device repeatedly may cause the deposition of large amounts of iron and other hemoglobin degradation products in the tissue of the penis causing hemosiderosis, which ultimately results in fibrosis. Without binding itself to any particular theory, applicant believes that this invention works by inducing biological creep (induction of cellular processes for tissue remodelling and cellular growth) and, to a lesser degree, biomechanical creep (mechanical microscopic tearing and viscoelastic stretching of the connective tissue). The mechanical device may also be used to prolong retention of any pharmacological agent used to potentiate the effect of the composition,.e., the potentiator.
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Retrieved Johanson, Sue (2011). In addition, an agent which increases solubility of collagen may be used as a potentiator. "The role of vacuum erection devices in penile rehabilitation after radical prostatectomy". The term penis girth refers to the largest measured value obtained for circumference of the erect penis, as measured in the midshaft region (middle third). A sufficient-quantity was administered to maintain a prolonged engorgement of 60-90 over a period of about 3.5 hours. The active ingredient is a compound which causes vasodilation,.g., a vasodilator. The penis may be visually inspected and palpated to determine the extent of the response to the composition.